Fig. 1

Conventional sized-based response assessment metrics in responders and partial/non-responders comparing changes in diameter (RECIST), multiplication of the longest and perpendicular cross-sectional diameters (WHO), and volume at post-chemo (PC) and post-radiation (PRT) with respect to baseline (BL). The green and red vertical lines indicate partial response and progression thresholds, respectively, for RECIST, WHO, and volume. RECIST, WHO and Volume analysis all show universal pseudo progression at PC and stability at PRT, rendering these size-based metrics useless to separate R vs PR/NR